In celebrex a clinical study, the generic concomitant use of generic an nsaid and celebrex aspirin was generic associated with a significantly increased incidence celebrex of GI celebrex adverse reactions celebrex as celebrex compared to celebrex use of the nsaid alone see celebrex warnings AND precautions. Celebrex celebrex side effects celebrex 100 mg - is a white and generic blue colored capsule with the pill imprint 7767 100; Celebrex 200 mg - is a white and generic gold colored capsule with the pill imprint 7767 200. Because relatively few celecoxib patients celebrex overall (5.8 470/8072) dose-escalated to generic 200 mg twice daily, the results of the precision trial are not suitable for celebrex determining the relative CV safety of celecoxib at 200 mg twice daily celebrex compared to ibuprofen and celebrex naproxen at the doses taken. Case-control and cohort epidemiological studies showed that concomitant use of drugs generic that interfere with serotonin reuptake and an nsaid may potentiate the risk of bleeding more than generic an nsaid alone. Prescription medications can be generic expensive, and while generic versions can save you money, even they can be too costly. Disseminated Intravascular Coagulation (DIC) Because of the risk of disseminated intravascular coagulation with use of celebrex in celebrex pediatric patients with systemic onset JRA, monitor celebrex patients for signs generic and symptoms of abnormal clotting or generic bleeding, and inform patients and their. In the general.S. In patients with JRA who are known or suspected to be poor CYP2C9 metabolizers, consider using alternative treatments. During concomitant use of celebrex and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor generic for signs of worsening renal function see warnings AND precautions. Additionally, fluid retention and edema have been observed in some patients treated with nsaids. You may report side effects to FDA at 1-800-FDA-1088. Some of the products generic we feature are from partners. Table 1: Adverse Events Occurring in 2 of celebrex Patients from Pre-marketing Controlled Arthritis Trials CNX N414 6 celebrex Placebo N1864 NAP N1366 DEF N387 IBU N345 Gastrointestinal Abdominal Pain.126.96.36.199.0 Diarrhea.6.8. Heres how we make money. Celebrex and the generic Celecoxib is available online through Canadian Pharmacy World. The types of adverse events reported in the AS studies were similar to those reported in the OA/RA studies. Actavis has commercial operations in more than 60 countries and operates more than 30 what is celebrex manufacturing and distribution facilities around the world. See Use In Specific populations, and clinical pharmacology. Before taking nsaids, tell your healthcare provider about all of your medical conditions, including if you: have liver or kidney problems have high blood pressure have asthma are pregnant or plan to become pregnant. Specific Populations Geriatric At steady state, elderly subjects (over 65 years old) had a 40 higher Cmax and a 50 higher AUC compared to the young subjects. In some cases, its even prescribed for intense menstrual pain or polyps in the colon or rectum. There are important drug interactions to review when taking Celebrex. Atomoxetine and celecoxib may enhance the exposure and toxicity of these drugs. Strategies To Minimize The GI Risks In nsaid-Treated Patients Use the lowest effective dosage for the shortest possible duration. If these occur, instruct patients to stop celebrex and seek immediate medical therapy see warnings AND precautions, Use In Specific Populations. Celebrex is a brand name celebrex of celecoxib, celebrex approved by the FDA in the following formulation(s celebrex (celecoxib - capsule;oral celebrex manufacturer: GD searle, approval date: December 31, 1998. In patients who are elderly, volume-depleted generic (including those on diuretic therapy or have renal impairment, co-administration of an nsaid with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. Patients on celebrex and concomitant low-dose ASA (N882) experienced 4-fold higher rates of complicated ulcers compared to those not on ASA (N3105). Fun With Kids and More Ways to Live With OA in Pictures. Post-MI Patients Observational studies conducted in the Danish National Registry have demonstrated that patients treated with nsaids in the post-MI generic period were at increased risk of reinfarction, CV-related death, and all-cause mortality beginning in the first week of treatment. To minimize the potential risk for an adverse CV event in nsaid-treated patients, use the lowest effective dose for the shortest duration possible. Special Populations Hepatic Impairment In patients with moderate hepatic impairment (Child-Pugh Class B reduce the dose. A randomized celebrex controlled trial entitled the Prospective Randomized Evaluation of Celecoxib Integrated Safety. Precautions, celebrex is contraindicated in the setting of coronary artery bypass graft (cabg) surgery. Effectiveness of generic Celebrex (celecoxib) is no different. The effects of celebrex on labor and delivery in pregnant women are unknown. In addition, rare, sometimes fatal, cases of severe hepatic injury, including fulminant hepatitis, liver necrosis, and hepatic failure have been reported. These metabolites are inactive as COX-1 or COX-2 inhibitors. When nsaids including celecoxib are used in patients with systemic onset JRA, monitor patients for signs and symptoms of abnormal clotting or bleeding, due to the risk of disseminated intravascular coagulation. Hypertension, acute renal failure, respiratory depression, and coma have occurred, but were rare see warnings AND precautions. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. In the APC ( celebrex Adenoma Prevention with Celecoxib) trial, there was about a threefold increased risk of the composite endpoint of cardiovascular death, MI, or stroke for the celebrex 400 mg twice daily and celebrex 200 mg twice daily treatment arms compared to placebo. Clinical Studies Osteoarthritis celebrex has demonstrated significant reduction in joint pain compared to placebo. Median exposures for celebrex (n 3,987) and diclofenac (n 1,996) celebrex were 9 celebrex months while ibuprofen (n 1,985) was 6 months. Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that nsaids reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. Elimination Metabolism Celecoxib metabolism is primarily mediated via CYP2C9. Colon Polyps (Symptoms, Causes, Types, Treatment, Prevention). The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years. Differences in the incidence of complicated ulcers between celebrex and the combined group of ibuprofen and diclofenac were not statistically significant. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency celebrex or establish a causal relationship to drug exposure Cardiovascular: Vasculitis, deep venous thrombosis General: Anaphylactoid reaction, celebrex angioedema Liver and. In the class study, the Kaplan-Meier cumulative rates at 9 months of peripheral edema in patients on celebrex 400 mg twice daily (4-fold and 2-fold the recommended OA and RA doses, respectively ibuprofen 800 mg three times daily. Revised: Jun 2018 Side celebrex Effects side effects The following adverse reactions are discussed generic in greater detail in other sections of the labeling: Cardiovascular Thrombotic Events see warnings AND precautions GI Bleeding, Ulceration and Perforation see warnings AND precautions Hepatotoxicity see warnings. Table 5: Primary Analysis generic of the Adjudicated aptc Composite Endpoint Intent-To-Treat Analysis (ITT, through month 30) Celecoxib Ibuprofen Naproxen N 8,072 8,040 7,969 Subjects with Events 188 (2.3) 218 (2.7) generic 201 (2.5) Pairwise Comparison Celecoxib. Celebrex is not a substitute for low dose aspirin for cardiovascular protection. Rxrevu, and sign up for their coupons or click on their ads. Serious Skin celebrex Reactions Serious skin reactions have occurred following treatment with Celebrex, including erythema multiforme, exfoliative dermatitis, Stevens-Johnson Syndrome ( SJS toxic epidermal necrolysis (TEN drug reaction with eosinophilia and systemic symptoms (dress and acute generalized exanthematous pustulosis (agep). Exacerbation Of Asthma Related To Aspirin Sensitivity A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps ; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other nsaids. Pharmacokinetics Celecoxib exhibits dose-proportional increase in exposure after oral administration up to 200 mg twice daily and less than proportional increase at higher doses. Contraindications celebrex is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to celecoxib, any components of the drug product see warnings AND precautions. The long-term cardiovascular toxicity in children exposed to celebrex has not been evaluated and it is unknown if long-term risks may be similar to that seen in adults exposed to celebrex or other COX-2 selective and non-selective nsaids (see boxed warning. In the endoscopic studies, approximately 11 of patients were taking aspirin ( 325 mg/day). Laboratory Monitoring Because serious GI bleeding, hepatotoxicity, and renal injury can occur without warning symptoms or signs, consider monitoring patients on long-term nsaid treatment with a CBC and a chemistry profile periodically see warnings AND precautions. Please visit, nerdWallets health hub for our latest content. The calculated average daily infant dose was 10-40 mcg/kg/day, less than 1 of the weight-based therapeutic dose for a two-year old-child. Therefore, generic the daily recommended dose of celebrex capsules should be reduced by approximately 50 in patients with moderate (Child-Pugh Class B) hepatic impairment. There was no substantial difference in the number of clinical exacerbations of uveitis or systemic features of JRA among treatment groups. Do not take nsaids: if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other nsaids. In the setting of coronary artery bypass graft (cabg) surgery see warnings AND precautions. This effect has been attributed to nsaid inhibition of renal prostaglandin generic synthesis. Intervention Monitor patients with concomitant use of celebrex with corticosteroids for signs of bleeding see warnings AND precautions. Patients taking angiotensin converting enzyme (ACE) inhibitors, thiazide diuretics or loop diuretics may have impaired response to these therapies when taking nsaids see drug interactions. Females And Males Of Reproductive Potential Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated nsaids, including celebrex, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Twice-daily administration of 50 mg capsules to JRA patients weighing 12 to 25 kg and 100 mg capsules to JRA patients weighing 25 kg should achieve plasma concentrations similar to those observed in a clinical trial that demonstrated the non-inferiority. For patients 10 kg to 25 kg the recommended dose is 50 mg twice daily. Use of celecoxib may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers ARBs) see drug interactions. These events can occur at any time during generic use and without warning symptoms. Safety and efficacy have not been studied beyond six months in children. In vivo studies have shown the following: Aspirin When nsaids were administered with aspirin, the protein celebrex binding of nsaids were reduced, although the clearance of free nsaid was not altered. Naproxen HR (95 CI).93 (0.76,.13).86 (0.70,.04).08 (0.89,.31) Modified Intent-To-Treat Analysis (mITT, on treatment plus celebrex 30 days, through month 43) Celecoxib Ibuprofen Naproxen N 8,030 7,990 7,933 Subjects with Events 134 (1.7) 155 (1.9) 144 (1.8) Pairwise Comparison Celecoxib. Drug Interaction Studies In vitro studies indicate that celecoxib is not an inhibitor of cytochrome P450 2C9, 2C19 or 3A4. Warnings Precautions warnings Included as part of the precautions section. Osteoarthritis For OA, the dosage is 200 mg per day administered as a single dose or as 100 mg twice daily. When celebrex is used in patients with preexisting asthma (without known aspirin sensitivity monitor patients for changes in the signs and symptoms of asthma. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. Multisource drug products listed under the same heading (i.e., identical active generic ingredients(s dosage form, and route(s) of administration) and having the same strength (see Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents) generally will be coded AB if a study is submitted demonstrating bioequivalence. Drinking and smoking increases this risk. Our experts uncover ways to spend time with your kids. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. Intervention: During concomitant use of celebrex and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. These changes resulted in a statistically significant and clinically meaningful difference.9 mmHg (p0.0009) between celecoxib and ibuprofen and a non-statistically significant difference.8 (p0.119) mmHg between celecoxib and naproxen. The difference in rates between celebrex alone and celebrex with ASA groups may be due to the higher risk for GI events in ASA users. Menstruation, menstruation (menstrual cycle) is also referred to as a "period." When a woman menstruates, the lining of the uterus is shed. Celecoxib also falls into the category known as a non-steroidal anti-inflammatory drug (nsaid). In animal studies, nsaids, including celecoxib, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth. Treatment includes ice, rest, and. A total daily dose of 200 mg has been shown to be equally effective whether administered as 100 mg twice daily or 200 mg once daily. Inform patients of the warning signs and symptoms of hepatotoxicity (e.g., nausea, fatigue, lethargy, diarrhea, pruritus, jaundice, right upper quadrant tenderness, and flu-like symptoms). Celebrex has no effect on methotrexate pharmacokinetics. Celebrex at doses of 100 mg twice daily, 200 mg once daily and 400 mg once daily was shown to be statistically superior to placebo in these studies for all three co-primary efficacy measures assessing global pain intensity (Visual Analogue Scale. Patient Counseling Information Advise the patient to read the FDA-approved patient labeling ( Medication Guide ) that accompanies each prescription dispensed. It causes symptoms like stiffness and. Patients with severe hepatic impairment (Child-Pugh Class C) have not been studied. Side effects should also be reviewed. According to the FDA, like all nsaid medications, generic celecoxib will "have a Boxed Warning in their prescribing information (label) to alert health care professionals and patients about the risk of heart celebrex attack or stroke that can lead to death. Alternative therapies for treatment of JRA should be considered in pediatric patients identified to be CYP2C9 poor metabolizers see Poor Metabolizers of CYP2C9 substrates. These factors include, among others, the impact of competitive celebrex products and pricing; the timing and success of product launches; difficulties or delays in manufacturing; the availability and pricing of third party sourced products and materials; successful compliance with FDA and other governmental. What Dosages and Forms is Celebrex available in? If your doctor has prescribed brand-name drug Celebrex or generic Celebrex known as celecoxib, you likely have questions about cost, and rightfully. Since these 12 trials were of different durations, and patients in the trials may not have been exposed for the same duration of time, these percentages do not capture cumulative rates of occurrence. By undell, healthDay Reporter, friday, May 30, 2014 (HealthDay News) - The.S. For such patients, as well as those with active GI bleeding, consider alternate therapies other than nsaids. Intervention: Concomitant use of celebrex and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding see warnings AND precautions. These results are to be expected in patients with a prior history of ulcer disease see warnings AND precautions and adverse reactions. The generic Celecoxib comes from UK, Canada and India also called Cobix. The mean minimum lithium concentration increased 15, and the renal clearance decreased by approximately. Manufacturer: GD searle, approval date: August 29, 2002, strength(s 400MG. You may find your physician has samples available or resources that can lower your prescription costs even further. Precautions, description, celebrex (celecoxib) capsule is a nonsteroidal anti-inflammatory drug, available as capsules containing 50 mg, 100 mg, 200 mg and 400 mg celecoxib for oral administration.
Gastrointestinal bleeding has occurred. Podawanie, doustnie, ostrzeenia, silnie dziaajcy (B) Wydawanie Na recept Rp Rejestracja Decyzja o dopuszczeniu (leki) Opakowanie handlowe 10 kaps. Choroba zwyrodnieniowa staww: zwykle zalecana dawka wynosi 200 mg na dob w celebrex 1-2 dawkach podzielonych. At 50 mg/kg/day (approximately 6-times human exposure based on the celebrex AUC0-24 at 200 mg twice daily) there was increased preimplantation loss. Celekoksyb naley stosowa ostronie u pacjentw z niewydolnoci minia sercowego, zaburzeniami czynnoci lewej komory lub nadcinieniem, oraz u pacjentw z istniejcymi uprzednio obrzkami z rnych przyczyn, poniewa hamowanie prostaglandyn moe pogorszy czynno nerek i doprowadzi do zatrzymywania pynw. Wystpowanie w wywiadzie astmy, ostrego zapalenia bony luzowej nosa, polipw w jamie nosowej, obrzku celebrex naczynioruchowego, pokrzywki lub innej reakcji alergicznej po przyjciu kwasu acetylosalicylowego lub nlpz, w tym selektywnych inhibitorw COX-2. In celebrex a clinical study, the concomitant use of celebrex an nsaid and celebrex dosage aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the nsaid alone see warnings AND precautions. Renal toxicity celebrex has also been seen in patients celebrex in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Renal Toxicity And Hyperkalemia Renal Toxicity Long-term celebrex administration of nsaids has resulted in renal papillary necrosis and other renal injury. Avoid use of nsaids, including celebrex, in pregnant women starting at 30 weeks of gestation. Right before or celebrex after heart bypass surgery. Disseminated Intravascular Coagulation (DIC) Because of the risk of disseminated intravascular coagulation with use of celebrex in pediatric patients celebrex with systemic onset JRA, monitor patients for celebrex signs and symptoms of abnormal clotting or bleeding, and inform patients and their. What will it do for celebrex me? Strategies To Minimize The GI Risks In nsaid-Treated Patients Use the lowest effective dosage for the shortest possible duration. Hepatotoxicity Elevations of ALT or AST (three or more times the upper limit of normal ULN) have been reported in approximately 1 of nsaid-treated patients in clinical trials. What Are the Key Things I Need to Know About Celebrex? The chemical name is benzenesulfonamide and is a diaryl-substituted pyrazole. In May 2014, the FDA approved the generic version of celecoxib. Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trials (treatment durations up to 12 weeks; see Adverse events from celebrex pre-marketing controlled arthritis trials, above). Trudno dostpny w aptekach, opis produktu Celebrex, poka zdjcie i opis - owiadczam, e jestem zawodowo zwizany z farmacj lub medycyn. These metabolites are inactive as COX-1 or COX-2 inhibitors. Of the celebrex-treated patients in the pre-marketing controlled clinical trials, approximately 4,250 were patients with OA, approximately 2,100 were patients with RA, and approximately 1,050 were patients with post-surgical pain. Read the complete FDA warnings on Celebrex and celecoxib. Call your doctor for medical advice about side effects. Storage And Handling celebrex (celecoxib) 50 mg capsules are white, with reverse printed white on red band of body and cap with markings of 7767 on the cap and 50 on the body, supplied as: NDC Number Size bottle. 3 Baza KS-bloz udostpniana przez Producenta Bazy KS-bloz w treci portalu oraz moe by wykorzystywana w celach niekomercyjnych, przez osoby fizyczne, poszukujce informacji na temat produktw leczniczych lub suplementw diety, dostpnych w sprzeday na terenie Polski. Always seek celebrex the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The researchers noted, though, that more study needs to be done to determine its safety and effectiveness long-term. Uroda, stan naszych paznokci celebrex wiele mwi o naszym zdrowiu. Ambulatory Blood Pressure Monitoring (abpm) Substudy In the precision-abpm substudy, among the total of 444 analyzable patients at Month 4, celecoxib dosed at 100 mg twice daily decreased mean 24-hour systolic blood pressure (SBP).3 mmHg, whereas ibuprofen. Rheumatoid Arthritis For RA, the dosage is 100 to 200 mg twice daily. In healthy adult volunteers, the overall systemic exposure (AUC) of celecoxib was equivalent when celecoxib was administered as intact capsule or capsule contents celebrex sprinkled on applesauce. Celebrex, at doses up to 200 mg twice daily, can be administered without regard to timing of meals. Seek emergency help if any anaphylactic reaction occurs. Avoid taking nsaids after a recent heart attack, celebrex unless your healthcare provider tells you to.
The dosage clinical significance of celebrex this abnormality has not been established. Clinical Studies, juvenile Rheumatoid Arthritis (JRA for the management of the signs and celebrex symptoms of JRA in celebrex patients 2 years and older see. No substantial differences in dosage effectiveness were observed between these subjects and younger subjects. The sprinkled capsule contents on dosage applesauce are stable for up to celebrex 6 hours under refrigerated conditions (2-8 C/ 35-45 F). Renal Impairment celebrex is not recommended in patients with severe renal insufficiency see warnings AND precautions and clinical pharmacology. Dosage for short-term pain dosage Adult dosage (ages 18 years and older) The typical dosage is 400 mg for the first dose, followed by a 200-mg dose about 812 hours later if needed. Do not take any more dosage celecoxib until you speak to your doctor. Clinical monitoring Your doctor celebrex will check your blood pressure before and during treatment with celecoxib. The long-term cardiovascular toxicity in children exposed to celebrex has not been evaluated and it is unknown if the long-term risk may be similar to that seen in adults exposed to celebrex or other COX-2 selective and non-selective nsaids (see boxed warning, warnings AND precautions. Case-control and cohort epidemiological celebrex studies showed that concomitant use of drugs that interfere with serotonin dosage reuptake and an celebrex nsaid dosage may potentiate the risk of bleeding more than an dosage nsaid alone. Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. More than 8,500 patients received a total daily dose of celebrex of 200 mg (100 mg twice daily or 200 mg once daily) or more, including more than 400 treated at 800 mg (400 mg twice daily). The effective half-life is approximately 11 hours under fasted conditions. Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trials (treatment durations up to 12 celebrex weeks; see Adverse events from celebrex pre-marketing controlled arthritis trials, above). In a Danish National Registry study of patients with heart failure, nsaid use increased the risk of MI, hospitalization for heart failure, and death. The effects of celebrex on labor and delivery in pregnant women celebrex are unknown. Data Human Data The available data do not establish the presence or absence of developmental toxicity related to the use of Celebrex. Single doses see dosage AND administration of celebrex provided pain relief within 60 minutes. AHA/ACC Heart Failure Guidelines; Circulation. A dosage adjustment may be warranted when celecoxib is administered with CYP2C9 inhibitors or inducers. Rheumatoid arthritis (the inflammatory type of arthritis). It is primarily metabolized by CYP2C9 with a half-life of approximately 11 hours. The increases in both celecoxib dose groups versus placebo-treated patients were mainly due to an increased incidence of myocardial infarction. Arthritis: Causes and Treatment for Joint Stiffness and Pain. Celecoxib has not been studied in patients under the age of 2 years, in patients with body weight less than 10 kg (22 celebrex lbs and in patients with active systemic features. In controlled clinical trials the incidence of anemia was.6 with celebrex and.4 with placebo. 400 mg white, with reverse printed white on green band dosage with markings of 7767 on the cap and 400 on the body. Reactive Arthritis Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint. Your doctor may also do blood tests to check how well your liver and kidneys are functioning during treatment. Dont put this medication in your cars glove compartment or leave it in the car. Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleeding. Discover rheumatoid arthritis (RA) symptoms. All patients were prescribed open-label esomeprazole (20-40 mg) for gastroprotection. If your symptoms are severe, call 911 or go to the nearest emergency room. A dose-dependent increase in diaphragmatic hernias was observed when rats were given celecoxib at oral doses 30 mg/kg/day (approximately 6 times human exposure based on the AUC0-24 at 200 mg twice daily for RA) throughout organogenesis. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. See dosage AND administration and clinical pharmacology. Poor Metabolizers Of CYP2C9 Substrates In patients who are known or suspected to be poor CYP2C9 metabolizers (i.e., CYP2C9*3 3 based on genotype or previous history/experience with other CYP2C9 substrates (such as warfarin, phenytoin ) administer celebrex starting with half the lowest recommended dose. In animal reproduction studies, embryo-fetal deaths and an increase in diaphragmatic hernias were observed in rats administered celecoxib daily during the period of organogenesis at oral doses approximately 6 times the maximum recommended human dose of 200 mg twice daily. It works by stopping the body's production of a substance dosage that causes pain and inflammation. Mutagenesis Celecoxib was not mutagenic in an Ames test and a mutation assay in Chinese hamster ovary (CHO) cells, nor clastogenic in a chromosome aberration assay in CHO cells and an in vivo micronucleus test in rat bone marrow. See dosage AND administration, Use In Specific Populations. Avoid use of nsaids, including celebrex, in pregnant women starting at 30 weeks of gestation.